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however, this shift is constrained for many species (e.g., Chinese amphibians) due to dispersal barriers and habitat fragmentation (Robillard et al., 2015)

For example, patients refractory to IMiDs in earlier lines of therapy regained sensitivity to lenalidomide or pomalidomide following in vivo treatment with Daratumumab (106)

Its anti-inflammatory properties and ability to reduce oxidative stress in the skin can also help alleviate the symptoms of melasma

Kumar et al., 2016), could help in understanding if such mutations are purely deleterious as commonly thought, or if they confer acute survival benefits despite long-term negative consequences, thus supporting MAD from a different angle

Common pharmacological treatments include antithyroid drugs such as propylthiouracil (PTU), methimazole (MMI), carbimazole, and levothyroxine (LT4) (Ling et al

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