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This peripheral restriction is fundamentally different from compounds like Semaglutide (a GLP-1 agonist that acts centrally to reduce appetite) or ghrelin-modulating agents that directly influence hunger hormones

Vitamin B12 injections are also not a proven weight-loss treatment

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In reality, the amount is minimal and biologically insignificant for healthy individuals

Disagreements were resolved through discussion or by consultation with a fourth author (CS)