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[PMC free article] [PubMed] [Google Scholar] 4.Graham ID, Jette N, Tetroe J, Robinson N, Milne S, Mitchell SL

Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and interaction with hormonal regulation of the breast

After antigen presentation, CD8+ T cells exert cytotoxic effects on pathogens by introducing a large payload of molecules such as granzymes and perforin, both of which induce apoptosis via cell membrane lysis