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216 In addition, PRMT4-catalyzed asymmetric dimethylarginine (ADMA) has been reported to bind to NOS as a ligand, leading to NOS dysfunction, resulting in decreased cerebral blood flow and aggravating AD, which can be reversed by inhibition of PRMT4

This effect, depending on the situation may significantly contribute to worsening diseases and infections, and/or increase the risk of subsequent infection, with possible life-threatening implications [93]

Source and distribution of human MPs Humans are generally exposed to MPs/NPs through three primary pathways: oral intake, respiratory absorption, and penetration through the skin 17

a key role of Nrf2 is initiating the transcription of antioxidant and cytoprotective genes in microglia [124]

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Of more than 100 cannabinoids in the plant, delta-9-tetrahydrocannabinol (THC) is the main psychoactive compound, which alters the mind or behavior