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J Lipid Res 2019

Maintaining adequate levels of folic acid is essential for men, as it plays a vital role in maintaining sperm shape and preventing abnormalities

So if you take somebody who already has autoimmune disease and they go without estrogen, now I see so often there is inflammation that we, this is when, this is generally, you know what I see when someone is not getting adequate treatment, which might be estrogen hormone replacement therapy, that now they're developing more autoimmune diseases because estrogen helps us regulate our immune system, as does testosterone

Therefore, we hypothesize that peripheral target engagement in SOD1 G93A mice could prove to have effects by amelioration of peripheral hypermetabolism and thereby, e.g., inflammation and oxidative stress

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