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Figure 5 The proliferation, differentiation, and survival of intestinal epithelial cells are regulated by cytokines, such as TNF- and IL-6 (32)

DIM has been shown to reduce DNA hypermethylation of CpG islands (hallmark feature of cancer activity), reduce intestinal inflammation, function to mildly inhibit aromatase, and enhance DNA repair mechanisms

This phenomenon may lead to treatment failure and cancer recurrence

In experimental retinal models, RvD1 reduces leukocyte adhesion and vascular leakage, while neuroprotectin D1 protects retinal pigment epithelial and neuronal cells from oxidative stressinduced apoptosis

Orwar et al

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