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For instance, IGF-I attenuated the response of theMCF-7 BC cell line to doxorubicin and paclitaxel by at least two mechanisms: induction of proliferation and inhibition of apoptosis (Zeng et al., 2009)

Gene set enrichment analysis of the PC1 loadings showed E2F and MYC targets and mTORC1 pathway genes in the top ten under both normoxic and hypoxic conditions, with hypoxia and glycolysis genes under normoxic conditions and oxidative phosphorylation, and epithelial mesenchymal transition genes under hypoxic conditions (Supplementary Table 4)

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Newly developed targeted therapies against the androgen receptor in triple-negative breast cancer: a review

These early clinical studies were paralleled by experimental studies in rodent models

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