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Ethacraplatin is also able to revert cisplatin resistance in microsomal GST1-1 overexpressing cells 94

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2.6.7 Transwell migration and invasion assay Cells were pretreated with 0 or 50 nM 4-EA for 48 h before seeding into the chamber

Treatment is limited, however, by side effects including nephrotoxicity, emetogenesis and neurotoxicity

This article review extensively explores the relationship between the p53/p21 pathway and cellular senescence within an aging kidney and the emerging therapeutic strategies that target it to overcome the impacts of cellular senescence on CKD
