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Supporting this, VPA-exposed rats characterized by reduced cerebrospinal oxytocin levels and a decreased number of oxytocin-immunoreactive cells in the hypothalamus exhibited normalization of these parameters as well as rescue of the ASD-like phenotype following treatment [31]

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These studies are needed to accurately determine the optimal intake levels of hormetic compounds for promoting health, including careful consideration of the effects of low-dose exposure over extended periods and the identification of relevant biomarkers that can indicate hormetic responses

If a tiny capillary is contacted, light bruising may occur, but this is minor and resolves without treatment

but, at the high dose (8 mg/kg/day), most of the animals succumbed by the end of the first week of treatment and others that survived presented signs of peritonitis [329]

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