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However, certain medications can affect B12 absorption, including metformin (used for diabetes), proton pump inhibitors, H2-receptor antagonists, and colchicine

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It has been given FDA approval as an orphan drug

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malabsorption (insufficient absorption of vitamin B12 in the intestine), insufficient production of intrinsic factor (a protein that is formed in the stomach lining and required to absorb vitamin B12), Diseases in the end section of the ileum (part of the small intestine), e.g