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Case summary A 67-year-old woman presented to the hospital with a 6-month history of fatigue and unintentional weight loss from loss of appetite and was found to have antibodies against intrinsic factor on laboratory workup after undergoing upper endoscopy

Adequate levels of vitamin B12 help maintain healthy red blood cell production

Skin and hair also rely on protein, iron, zinc, vitamin D, and vitamin C, and gaps can show up as shedding, slow wound repair, and fragile nails that split

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Additional research indicates low levels of vitamin B12 may increase the risk of macular degeneration

Mass spectrometry can detect these errors, but only if the reference molecular weight matches the intended structure