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This physiological redox tone integrates with other layers of control, including mitochondrial bioenergetics, iron and glutathione metabolism and calcium homeostasis (Zhao et al
Nanodrug delivery systems for ferroptosis-based cancer therapy

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Introduction The first reports about a plant glutathione S-transferase enzyme (GST, EC 2.5.1.18) appeared in 1970, when it was revealed that a GST catalyzed the detoxification of the herbicide atrazine by its conjugation to the endogenous tripeptide glutathione (GSH, -L-glutamyl-L-cysteinyl-glycine) in sorghum and maize plants (Frear and Swanson, 1970)

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In mammals, the cytosolic GSTs can be divided into five distinct classes termed alpha, mu, pi, sigma and theta