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Timeline depends on the individual but the gap is noticeable

It is useful in a multitude of processes, cellular proliferation, cell division, and differentiation, and is the most commonly elevated metabolite detected during oxidative stress

Yao et al

Inside the neutrophil phagosome: Oxidants, myeloperoxidase, and bacterial killing
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A novel automated method to measure total antioxidant response against potent free radical reactions
