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These are substances that the FDA itself has said present potential safety risks because of a lack of study of their effects on humans

Use of trimethoprim-sulfamethoxazole in a glucose-6-phosphate dehydrogenase deficient population

However, this leads to pericellular acidosis that often persists in tumor microenvironment because the acidic metabolic waste cannot be effectively removed by the abnormal tumor vasculature [12]
Frontiers in immunology, 8 , 598

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Strengthens the immune system, providing better protection against illnesses