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Falling is a risk factor for bone fractures among men and women 60 years of age and older

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By utilizing the K m ratio of humans (K m(human) = 37) to rats (K m(rat) = 8.5) calculation, the dose attained in the rats can be converted to a HED by dividing by 4.35, which is the K m ratio of humans to rats (adjusted for the rat size in this study) (Nair & Jacob, 2016)