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Similarly, IDH1-mutant tumors, which possess naturally lower basal NAD + levels, exhibit heightened sensitivity to NAMPT inhibition 193 , suggesting these specific subsets should be prioritized in future trials

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Austin J Clin Neurol

Our data demonstrate that a common mitochondrial uncoupler dinitrophenol, which extends the mouse lifespan 36 , induces tbb-6 expression similarly as does acivicin, further indicating that both chemicals target ETC (Fig