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Thirty-two percent were found to be below age-adjusted threshold values for vibratory sense on either upper or lower extremities using a Rydel-Seiffer 64 Hz tuning fork compared to an estimated, expected 5% in the general population (103)

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Within this process, First-in-Human (FIH) trials represent one of the most important transitions in the development of a new medicine

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Sigmoidal dose-response curves and reliable estimates of IC 50 values based on non-linear least-squares fitting to the available data could not be obtained since no significant inhibition of DNMT1 and PRMT3 was observed at the tested NNMT inhibitor concentrations (Table 3)