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This medicine is only one part of the treatment program which should also include a healthy diet, regular exercise, smoking cessation, moderation of alcohol intake, and weight reduction

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Botulinum toxin A has been shown to act at the level of the muscle spindle by inhibiting gamma motor neurons and blocking type Ia afferent signals, thus affecting both motor and sensory pathways

Retinoic acid is the form that does the work, binding to retinoid receptors (RAR and RXR) in cell nuclei and directly regulating gene expression
