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Besides UV exposure acrolein, a component of cigarette smoke, was shown to play a significant role in protein carbonylation, as shown in keratinocyte cell culture experiments [201]

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Removal of its signal peptide during insertion into the endoplasmic reticulum generates proinsulin which consists of 3 domains: an amino-terminal B-chain, a carboxy-terminal A-chain and a connecting peptide known as C-peptide

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[DOI] [PubMed] [Google Scholar] 46.Dringen R., Hamprecht B

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