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142 IGF-1 increases cellular senescence in VSMCs by inducing DNA damage and increasing ROS production via the p53 pathway

10.1038/mp.2016.189 114 KaushikR.MorkovinE.SchneebergJ.ConfetturaA

A key aspect of this conversion is that it supplies one-carbon units, which play a vital role in the folate and methionine cycles, central pathways in what is collectively known as one-carbon metabolism (Choi and Coloff 2019)

This one is essential for glucose metabolism

Pharmacotherapy of autism spectrum disorder: results from the randomized BAART clinical trial

Combining both agents could theoretically amplify appetite suppression and gastrointestinal effects, though long-term safety data on this specific combination is lacking