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Considering that glutathione is involved in the elimination of harmful substances such as: alcohol, drugs, solvents, pesticides, heavy metals, and many other toxic xenobiotic products that induce a state of cellular stress [71], it is evident that glutathione homeostasis becomes more relevant, because cells require an antioxidant agent that either prevents or reduces this stress, whether by trapping, metabolizing or turning them into less toxic agents [71,101]

There are two types of DILI: intrinsic and idiosyncratic

[cited 2023 June 22] 10

doi: 10.3389/fnins.2019.01400 408 QiYShangLLiaoZSuHJingHWuBet al