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Heme oxygenase-1 (HO-1), a rate-limiting enzyme in heme degradation, is critical for iron metabolism (Maamoun et al., 2019)

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Martin, B., Lopez de Maturana, R., Brenneman, R., Walent, T., Mattson, M

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Among all the poses from IFD, docked GSSG on C23 represents many polar contacts with several nearby residues on GLRX protein including hydrogen bonding with C83, N55, Y25, G82, P24, T22, and K20 which stabilizes the complex significantly

Furthermore, rats that received curcumin showed reduced levels of pro-inflammatory cytokines IL-6 and IFN