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The SURMOUNT-1 Phase 3 trial published in the New England Journal of Medicine demonstrated 20.9% mean body weight reduction at 72 weeks on tirzepatide 15mg weekly versus 3.1% with placebo
It influences energy metabolism by improving glucose homeostasis and insulin sensitivity and enhances glucose uptake and utilization in cells which leads to improved energy metabolism
Recently, it has gained attention for its off-label use in weight loss, providing an alternative for individuals struggling with obesity
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