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Additionally, FOXO transcription factors have recently been implicated in tumorigenesis: in fact, rhabdomyosarcomas present FOXO genes with a high percentage of mutations that render them insensitive to inhibition by AKT signaling 65

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Finseth TA, Hedeman JL, Brown RP 2nd, Johnson KI, Binder MS, Kluger BM

Respecto a dosis empleadas en estudios: la evidencia disponible proviene de modelos preclnicos (roedores e in vitro) diseados con esquemas especficos de cada modelo, y no se localizaron regmenes de dosificacin humana validados ni protocolos para la combinacin de los tres pptidos administrados juntos

doi: 10.1002/ajmg.a.61983