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Description
Upon release into the extracellular space, sTNF- binds to TNFR1 on target cells, triggering a downstream signaling cascade
Excess TNF has been shown to trigger programmed necrosis
M.ChenH.LiY.NgongaL.AmoahK.YongZ.et al
doi: 10.4049/jimmunol.158.12.5658 33 Al-MohannaFACollisonKSAllenSPSternDYacoubMH
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Glutathione 2
