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Pugliese NR, Paneni F, Mazzola M, De Biase N, Del Punta L, Gargani L, et al

Ethics declarations Ethics approval and consent to participate We declare that all experiments on human subjects were conducted in accordance with the Declaration of Helsinki and that all procedures were carried out with the adequate understanding and written consent of the subjects

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The secretion of these cytokines is a hallmark of macrophage activation and is crucial for initiating and amplifying an inflammatory response to pathogens or cellular stress (Liu and Liu, 2022)

Fleenor, D., Arumugam, R

Increased intestinal permeability facilitates the translocation of microbes, their components, and microbial products into the blood stream and their recognition by the host immune cells (Longo et al., 2020)