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collected data and contributed to writing the manuscript

Although this pathway is critical in erythropoiesis, owing to the role of polyamines in regulating the intracellular pH of hematopoietic precursors [114], in adult RBCs this pathway has been associated with cellular responses to iron-deficient anemia and abiotic stresses, such as exposure to radiation [115]

Aggrecan degradation in chondrocytes is mediated by reactive oxygen species and protected by antioxidants

In part, this may relate to a ceiling effect reached early in the disease course 164

Conversely, excessive supplementation with exogenous antioxidants can weaken these positive ROS-mediated signals

The drugs long-acting formulation, with monthly or bi-monthly dosing, could enhance patient adherence and long-term weight management