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Curr Med Chem 13:14611471

The relation between 7nAChRs and herbal medicine The cholinergic anti-inflammatory pathway and cognitive function depend on 7nAChRs, whose activity has been demonstrated to be modulated by herbal medicine

Further research indicates that this regulatory process is closely related to oxidative stress mediated by ROS and nitric oxide (NO) induced by inflammatory factors: ROS/NO promotes DMT1 expression and inhibits FPN1 function by upregulating iron regulatory protein 1 (IRP1) and hepcidin, ultimately forming a vicious cycle of iron overload-inflammation-iron retention [98]

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In addition, a fixed p -value cut-off of p 2 were considered significant contributors