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[1] Selectivity testing indicated the scaffold did not inhibit related SAM-dependent methyltransferases or NAD+ salvage enzymes

First, SELECT was not a primary prevention trial, and the data should not be extrapolated to all individuals with overweight and obesity to prevent major adverse CV events

Vitamin B12 likewise connects with folate in the body, so it could help reduce the danger of abnormality, such as neural tube flaws

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