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The decreased sensitivity of cancer cells to these inhibitors may be due to several reasons, including extracellular GSH binding to and inactivating the inhibitors
This reduced form is critical for glutathione's biological functions, as oxidized glutathione (GSSG) must be recycled back to its reduced form through enzymatic processes before it can provide antioxidant protection
Biol Psychiatry 64 : 538540
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Rodrguez-Rodrguez et al., 2014)
