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In collaboration with postdocs Tatiana Lima and Martin Minns, Karl helped identify a novel role for Pseudomonas aeruginosa exotoxin S ADP-ribosyltransferase activity in the activation of NLRP3 inflammasome in neutrophils

Clinical scenario #3: A patient with chronic liver disease who is interested in taking a supplement for which there is little evidence of harm, but who also has personal factors that increase his risk for harm Case A 48-year-old man with Child-Pugh A cirrhosis secondary to metabolic dysfunction and alcohol-associated steatotic liver disease without clinically significant portal hypertension has persistently elevated liver enzymes despite alcohol abstinence and engagement in the management of his metabolic risk factors

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Phase B: Dysfunction spreads across hormonal axes

These procedures aimed to maintain the intricate details of the sciatic nerve, including Bngner bands, Schwann cells, axons, and histiocytes, for high-resolution visualization under the TEM