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2010 reported that the FDA rejected a key study on Tylenol PM and Excedrin PM, finding no substantial benefit over acetaminophen or diphenhydramine alone

Aziz MT, Mostafa T, Atta H, Rashed L, Marzouk SA, Obaia EM, et al
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10.1542/peds.2012-0310 Pediatrics 48 GorlachA.BertramK.HudecovaS.KrizanovaO

The full breakdown of evidence and protocols is in the 5-Amino-1MQ complete guide

doi: 10.1210/jc.2004-2513
