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Special Precautions Administration of high doses of the oral formulations of levocarnitine for long periods of time is not recommended in patients with severely compromised renal function or in ESRD patients on dialysis due to the fact that major metabolites formed following oral administration trimethylamine (TMA) and trimethylamine-N-oxide (TMAO) will accumulate since they can not be efficiently removed by the kidneys

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[DOI] [PMC free article] [PubMed] [Google Scholar] Hattori T

Schaefer, F., Straube, E., Oh, J., Mehls, O

2017 Perceiving the Protohistoric: When Weak Signatures Represent the Strongest Cases