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This glycolytic enzyme is degraded through the ubiquitin-proteosome pathway by the action of the E3 ubiquitin ligase APC/C-Cdh1 (Fig

Grubb, A

Intraplantar injection of rIGF-1 (50 g/kg) increase the expression of c-raf and p-ERK, while JB1 (6 g/mouse) pretreatment significantly reduced p-ERK and c-raf levels in DRG[67]

Both have favorable safety profiles[42,27]

Wen C., Shan C., Sun W., Wan Y., Lin R., Chen B., Dai H., Tang K., Xiang X., Yang J., Li N., Yonghui H

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