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Metformin, an activator of AMPK and LKB1, could decrease hepatic tissue insulin resistance, and prolonged survival was observed in cancerous metformin users (Sadeghi et al., 2012

Loss of adipocyte Ssu72 improves glucose homeostasis under HFD-induced metabolic stress Obesity driven by excessive nutrient intake is commonly linked to impaired insulin sensitivity and disrupted glucose homeostasis [34]

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