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Methylglyoxal binds to various proteins, causing loss of function and abnormal aggregation, ultimately resulting in opacity 12

Choline and L-carnitine are metabolized to disease-associated metabolite trimethylamine (TMA) by the gut microbiota

By improving dysbiosis, gut microbiota targeted intervention has shown promising outcomes in significantly reducing levels of these toxins in CKD patients, which, in turn, reduces the rate of occurrence of CKD-associated complications, and further studies that focus on this outcome are currently being explored

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doi: 10.1016/0041-008x(89)90283-4