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In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs than the US, where market forces play a more significant role

Since then numerous patients have been treated with high dose vitamin B12 worldwide

However, development was discontinued in 2007 after the largest Phase IIb trial failed to demonstrate statistically significant weight loss compared to placebo

Whether administration of leptin could overcome leptin resistance and exert an anti-obesity effect was tested in a placebo-controlled study with 47 obese men and women given varying doses of recombinant human leptin (0.03 mg/kg and 0.30 mg/kg, respectively) for 24 weeks and advised to eat 500 kcal less than body requirements each day

This remains an area of investigational interest rather than documented clinical application

Full disclosure: Inform your healthcare provider about any existing medical conditions, especially diabetes, thyroid issues, or a family history of medullary thyroid cancer or multiple endocrine neoplasia type 2