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Increases in proinflammatory cytokine such as TNF, IL-4, IL-6 and IL-13 have all been shown to increase epithelial permeability and have been tied to increased expression of claudin-2 in animal and human models as well as decreased expression of JAM-A and occludin [152, 153]

For example, some compounds can inhibit the proliferation, growth, and migration of cancer cells through the PI 3K/Akt signaling pathway, MEK/ERK signaling pathway, and p53 signaling pathway, and exert the therapeutic effect of Radix Codonopsis on various systems of cancer through multi-target and multi pathway approaches, in order to provide reference for future research and clinical applications

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LL-37 binds not only to self-DNA but also to self-RNA, and activates TLR7 in pDCs and TLR8 in mDCs [97]

doi: 10.4049/jimmunol.1101186

Nucleus 9 , 216226 (2018)