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5,000 mcg daily is common in standalone B12 supplements

While each B Vitamin has distinct functions, they collectively contribute to energy metabolism, making them all vital for your overall health
PMID 11304860

B12 injection dosage I'm a 60 year old man living in the US

Heres the whole thing in plain terms: What they did: built and validated a lab-grade method to accurately measure 5A1MQ in the blood, then dosed rats two ways intravenous (IV) and oral and tracked exactly how much showed up in circulation over time

Naltrexone failed to produce consistent or clinically meaningful weight loss, even at large doses (300 mg/d) (60), implying that a single opioid mechanism is unlikely to explain all aspects of ingestive behavior
