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Description
Studies in human hepatoma cells have shown that GSTP1 is able to bind to signal transduction and transcriptional activator 3 (STAT3) to form the GSTP1-STAT3 complex, inhibiting epidermal growth factor (EGF)-mediated phosphorylation of STAT3 tyrosine and preventing its transcriptional activity, thereby reducing cell proliferation and halting the cell cycle [73]

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acidocaldarius GKs, belonging to the FGGY family within the sugar kinase/HSP70/actin superfamily, with significant similarity to both archaeal and bacterial enzymes, as well as eukaryotic counterparts

doi: 10.1155/2013/262039

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