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Decreased insulin-mediated suppression of adipocyte lipolysis has been reported in obese rats (118) as well as in women with visceral obesity (3, 54), although several other studies in humans report that the antilipolytic effects of insulin are well conserved, even in subjects with highly impaired insulin-mediated glucose regulation (7, 8, 11, 52)

In each case, a provider should confirm a deficiency before starting treatment

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Illnesses Any illness or condition that affects the digestive system can result in a B12 deficiency because the vitamin is bound to the protein molecules in your food and is released and absorbed by the body during digestion

TL;DR There is no single answer

Vegans and Vegetarians Since B12 is found almost exclusively in animal-based foods, individuals following plant-based diets are at a higher risk of deficiency