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IFN is the essential cytokine responsible for stimulating macrophage differentiation to the M1 phenotype 55,56

The presence of a large number of proteolytic enzymes and peptidases in the body is the primary reasons for this phenomenon (Sharma et al., 2013)

Drug Interactions CYP450 Enzyme Interactions CYP2C9 inhibition: Milk thistle may inhibit CYP2C9, which metabolizes several important medications including warfarin, amitriptyline, diazepam, and verapamil [1]

[DOI] [PMC free article] [PubMed] [Google Scholar] 124.Messina J.P., Lawrence D.A

If we consider the conditions clinically associated with severe COVID-19 disease [41,42,43], we find evidence of a perturbed GSH replenishment