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Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer

Ethics declarations Conflicts of interest The authors state that there is no conflict of interest

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FoxO3a transcription factors are involved in various cellular processes, with their primary role in mitigating DKD progression being linked to antioxidant activity ( Figure 4 4.2.2 Regulating the AMPK/Fox3a/Nrf2 pathway to inhibit ferroptosis AMPK is an enzyme widely expressed in the kidney, heart, and other tissues, serving as a sensor of cellular energy status

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Cultured rat hepatocytes also had elevated activities of these enzymes, whereas cultured human hepatocytes did not