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Each batch is independently analysed, with verification and documentation provided to support research traceability and consistency.

The main objectives to conceive and prepare this review paper were to 1) provide a summary of the state of angiogenesis inhibitors in the treatment of breast cancer, 2) analyze the factors attributing to the lack of efficacy of anti-angiogenic drugs, 3) explore new potential drug targets for angiogenesis inhibitors through non-VEGF/VEGFR signaling, and 4) describe novel approaches for targeting tumor vascularization and their potential implementation in breast cancer

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