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Acyl-CoA synthetase long-chain family member 4 (ACSL4), an enzyme involved in fatty acid metabolism, is considered as a specific biomarker and driver of ferroptosis because the upregulation of ACSL4 enhances the PUFA content in phospholipids, which are susceptible to oxidation reactions leading to ferroptosis

10.1128/JB.186.22.7815-7817.2004 131 SmithA

For each protein sequence in this CSD set, sequences in the corresponding 50% cluster of homologs from Uniprot were retrieved and aligned

J.ProbertC

This finding is consistent with the reported results that high infiltration of B cells predicts better responsiveness to immune blockage therapy [47,48,49]

(Spencer et al