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Depending on the specific context, reactive gliosis can be either beneficialpromoting improved functional outcomesor detrimental, leading to maladaptive impairments or neurodegeneration 377

Additionally, for patients with DILI specifically affecting liver cells (hepatocellular DILI), progressively worsening jaundice should also raise concerns and prompt evaluation for a potential liver transplant by a specialized center [130]

Nature 487 , 505509 (2012)

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This polymorphism is similar to the wild type NQO1*1, results in substitutional messenger RNA splice sites that can result in a deletion of exon 4 and produce a protein deficient in quinone binding site for which enzyme activity differs according to the substrate [ 61 , 62 , 63 ]

As our understanding of ferroptosis in PDAC continues to grow, so does the potential for developing more effective diagnostic, prognostic, and therapeutic approaches for this challenging malignancy (Table 2)