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11 Burris/Elgendy Lab, Saint Louis UniversityDiscovery and characterization of SLU-PP-332 as a pan-ERR agonist (synthetic small molecule)

In plant system as well as in humans, the status of the reduced form of cellular GSH and also that of its redox state is indicative of the reduced cellular environment capable of combating oxidative stress-impacts 2,4

Besides serving as energy substrates, free glutamine and glutamate are both specific precursors for glutathione, which is the main antioxidant in IECs and immune cells and critical for the prevention of cellular damage caused by pro-oxidants (94)

Based on these results, the 2 mg L 1 GSH-Au NCs concentration was identified as the optimal treatment and was selected for further analysis

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The RNA-dependent protein kinase-like ER kinase (PERK) pathway, one of the three apoptotic pathways of the endoplasmic reticulum, PERK/nuclear factor-E2-related factor 2 (Nrf2) play important roles in oxidative stress and ERS (45)