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Genome-wide association studies suggest that glutamatergic neurotransmission and NMDA receptor-mediated synaptic plasticity are important for body weight homeostasis 1

Although comprehensive mechanistic studies and clinical research on the combination of CDK4/6 inhibitors and anti-metabolic drugs are still limited, the combination of CDK4/6 inhibition with metabolic blockade holds great potential as an effective treatment option for patients in the future

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Role of PGC-1alpha signaling in skeletal muscle health and disease

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Studies have shown that BTZ can sensitize peripheral sensory nerve fibers, resulting in overactivity of WDR neurons and subsequent abnormal pain or nociceptive hypersensitivity (Stockstill et al., 2018
