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Furthermore, in FXN -silenced SH-SY5Y cell lines, Trolox, a lipid peroxidation scavenger and analogue of Vitamin E, improved Ca 2+ uptake and reduced lipid peroxidation ( It is apparent that oxidative stress is one of the main drivers of mitochondrial dysfunction in FRDA

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Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain

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Aspirin has also been shown to protect against acetaminophen-induced liver toxicity due to down regulation of proinflammatory cytokines rather than COX-1 inhibition [15]