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Description
When elevated levels are identified, systematic investigation is required to determine the underlying cause
doi: 10.1016/j.coph.2007.04.005 96 LiQLiaoJChenWZhangKLiHMaFet al
Future studies will reveal the applicability of our model, for example, to activate enzymatically inactive glutaredoxins, to alter the sensitivity and responsiveness of glutaredoxin-coupled fluorescent redox sensors, to further address the catalytic mechanism with GSSCys, HEDS and physiological substrates, or to design specific transition-state inhibitors
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